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Chemo-Immuno-Gene
Therapy for Malignant Brain Tumors
Translating encouraging preliminary results of novel
immuno-gene therapy, in combination with a novel molecular
genetic chemotherapy, into a new treatment for intracerebral
breast cancer. 2003 NeuroGrant Recipient
Immuno-Gene Therapy
for Malignant Brain Tumors
Translating encouraging preliminary results of novel
molecular genetic immunotherapy into the clinical setting.
Determining the safety and efficacy of treating human intracerebral
malignant tumors using genetically modified IL-2 secreting
cells as a tumor vaccine.
Early Detection of Brain Metastases from
Advanced Breast Cancer Through Education and Screening
A two part project which will: 1) provide educational information
to breast cancer patients regarding the prevalence of metastases
to the brain, available treatments, and the importance of
brain scans and early detection and 2) undertake a research
project which will examine the role of early screening for
brain metastases arising from breast cancer. 2006 NeuroGrant
Recipient
Immuno-Gene Therapy for Malignant Brain Tumors: A Clinical
Trial
Determine the safety and efficacy of treating human intracerebral
malignant tumors using genetically modified IL-2 secreting
cells transduced with the patient’s DNA, as a tumor vaccine.
2006 NeuroGrant Recipient
Epilepsy Database
Compilation of a comprehensive database containing diagnosis
and treatment parameters.
Molecular Biology of Epileptogenesis
A combination of human clinical studies and animal studies
to investigate the molecular basis of epileptogenesis. 2004
2005, and 2006 NeuroGrant Recipient
In Vivo, Hypothalamic Deep Brain Stimulation (DBS) for
Weight Loss in Rat Obesity Model
Evaluating the feasibility and effectiveness of chronic deep
brain stimulation of the feeding center, ventromedial hypothalamus
(VHM) of obese rats to effect weight loss. 2003 NeuroGrant
Recipient
Deep Brain Stimulation for Treatment of Obesity: Chronic
Stimulatory Inhibition of the Lateral Hypothalamic Area and
Effects on Food Intake and Weight in the Rat
Evaluating the feasibility and effectiveness of chronic deep
brain stimulation to the lateral hypothalamus of obese rats
to effect weight loss.
A Direct Brain-to-Speech Generator for Use in Humans
Investigating the possibility of direct brain-to-speech activity
in locked-in patients. 2004 NeuroGrant Recipient
Chronic Bilateral Deep Brain Stimulatory Inhibition of
the Lateral Hypothalamus for Treatment of Obesity in the Primate
To determine if bilateral deep brain stimulation of the Lateral
Hypothalamus will lead to significant and sustained weight
loss in primates. 2004 NeuroGrant Recipient
Impact of Deep Brain Stimulation in the Sub-Thalamic Nucleus
of Patients with Parkinson’s Disease on Behavior and
Mood
Prospective longitudinal study to assess the impact of deep
brain stimulation on behavior and mood in patients with idiopathic
Parkinson’s Disease. 2005 NeuroGrant Recipient
Safety and Efficacy of Deep Brain Stimulation (DBS) of
the Globus Pallidus Internus (Gpi) in Dystonia
Assessing the safety and efficacy of bilateral deep brain
stimulation of the Globus Pallidus Internus in medically refractory
dystonia. 2003 NeuroGrant Recipient
Host Immunological Response to Transplantation of Stem
Cells
Evaluating the immunological potential for the rejection of
stem cell grafts in the treatment of MPTP-induced Parkinson-like
symptoms. 2005 NeuroGrant Recipient
Microelectrode Signal Analysis
Elucidating the pathophysiology of patients with unusual diseases
undergoing deep brain stimulation through the analysis of
firing patterns. 2005 NeuroGrant Recipient
NPH Documentation
Pre – and post operative gait analysis using videography.
Predictors of Quality of Life (QOL) of Postoperative Spine
Patients: A Pilot Study
Describing variables that may predict the QOL of patients
who have undergone various types of spinal surgery for nonmalignant
spinal disease. Identifying potential risk factors of a poor
QOL outcome in the surgical spine population. 2003 NeuroGrant
Recipient
Predictors of Quality of Life (QOL) of Patients Undergoing
Lumbar Spinal Surgery
Describing the QOL of spinal surgery patients preoperatively
and three months following surgery. Identifying changes in
QOL of spinal surgery patients from the preoperative to the
postoperative period. Examining the relationship between symptom
status (pain and mood), functional status, perceived health
status, optimism, social support, expectations, response shift
and perceived QOL.
The Relationship
Between Exercise and Back Pain During Pregnancy: A Multidisciplinary
Study
Describing reports of back pain or discomfort and
correlating self-reports to patterns of physical activity.
Describing potential risk factors that may predispose a pregnant
female to experience back pain during pregnancy. Demonstrating
the applicability of selected pain scales used in the general
population in the pregnant population. 2003 NeuroGrant
Recipient
The Use of Musculoskeletal Ultrasound in
Low Back Pain
Identifying if musculoskeletal ultrasound can be used in the
clinic to assist patients in relieving low back pain by fine
tuning their exercise program and providing objective feedback.
2003 NeuroGrant Recipient
Intraoperative
C5 Monitoring and Palsy
Assess one application of intraoperative monitoring
and its efficacy in prevention of post-operative C5 palsies.
2004 NeuroGrant Recipient
Evaluation of a Multifidus Exercise Program
on the Cross-Sectional Area of the Multifidus Muscle for Recurrent
Low Back Pain
Determining the effect of a multifidus exercise program on
the cross sectional area of the multifidus muscle. 2005
NeuroGrant Recipient
Image Guided Placement of Thoracic Pedicle Screws
Determining the efficacy of image guidance in the placement
of thoracic pedicle screws. 2005 NeuroGrant Recipient
Aspiration of Synovial Cysts of the Lumbar Spine –
A Novel, Non-Operative Treatment of Radiculopathy
Investigating the efficacy of percutaneous facet joint synovial
cyst aspiration, a seldom used and relatively novel treatment
for decompressing synovial cysts of the lumbar spine. 2005
NeuroGrant Recipient
Spinal Cord Progenitor Cell Isolation and Growth
1) To produce a working protocol for culturing spinal cord
progenitor cells from the spinal cords of mammalian embryos
and human cadavers, 2.) to investigate simulated stress environments
in vitro on spinal cord progenitor cells, and efficacy of
methylprednisolone as a neuroprotective agent. 2004 NeuroGrant
Recipient
Predicting Outcomes of Surgery to Relieve Mechanical Back
Pain
To examine how accurately a surgeon can predict how well a
patient will do after surgery for mechanical pain. 2006
NeuroGrant Recipient
Prospective Randomized Study of Incidence and Treatment
of Deep Venous Thrombosis in Patients with High Grade Gliomas
Determining whether 3x daily administration of heparin (versus
2x) will significantly reduce the rate of DVT formation without
significantly increasing the post-operative complication rate.
2004 NeuroGrant Recipient
Endovascular Treatment of Cerebral Aneurysms Using the
Stent and Coil Technique – A Long Term Outcome Study
of Safety and Efficacy
Defining the long-term safety and efficacy of the stent and
coil technique for the treatment of cerebral aneurysms. 2005
NeuroGrant Recipient
Arteriovenous Malformations: A Retrospective Review
Evaluating treatment parameters and outcomes in AVMs treated
with radiosurgery.
Neuroendovascular Laboratory
Equipment and flow models for a hemodynamic neuroendovascular
laboratory to facilitate investigation into new techniques
and devices.
Sensory Glove Interface Monitoring Device for Neurosurgical
Applications
Advancing development of a sensory glove prototype with capabilities
to assist neurosurgeons in monitoring their suturing techniques
as well as providing a feed back on the state of the hand/surgical
tools and conditions during surgery.
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